Readily Accessible Unsymmetrical Unsaturated 2,6-Diisopropylphenyl N-Heterocyclic Carbene Ligands. Applications in Enantioselective Catalysis
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- 作者：Robert Tarrieu ; Adrien Dumas ; Jompol Thongpaen ; Thomas Vives ; Thierry Roisnel ; Vincent Dorcet ; Christophe Crévisy ; Olivier BasléMarc Mauduit
- 刊名：Journal of Organic Chemistry
- 出版年：2017
- 出版时间：February 17, 2017
- 年：2017
- 卷：82
- 期：4
- 页码：1880-1887
- 全文大小：525K
- ISSN：1520-6904
文摘
A new multicomponent procedure was applied to the synthesis of (a)chiral bulky unsymmetrical unsaturated 2,6-diisopropylphenyl N-heterocyclic carbene (NHC) precursors with excellent selectivity (up to 95%) and good yields. This approach offers access to new chiral NHC ligands, which have found successful applications in both copper-catalyzed asymmetric allylic alkylation and copper-catalyzed asymmetric borylation.