Pd-Catalyzed Synthesis of Aryl and Heteroaryl Triflones from Reactions of Sodium Triflinate with Aryl (Heteroaryl) Triflates
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- 作者：Lynette A. Smyth ; Eric M. Phillips ; Vincent S. Chan ; José G. Napolitano ; Rodger Henry ; Shashank Shekhar
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：February 5, 2016
- 年：2016
- 卷：81
- 期：3
- 页码：1285-1294
- 全文大小：513K
- ISSN：1520-6904
文摘
A novel method for Pd-catalyzed triflination of aryl and heteroaryl triflates using NaSO<sub>2sub>CF<sub>3sub> as the nucleophile is described. The combination of Pd<sub>2sub>(dba)<sub>3sub> and RockPhos formed the most effective catalyst. A broad range of functional groups and heteroaromatic compounds were tolerated under the neutral reaction conditions. The order of reactivity ArOTf ≥ ArCl ≥ ArBr is consistent with transmetalation being a slow step of the reaction.