Nanovesicles Based on Self-Assembly of Conformationally Constrained Aromatic Residue Containing Amphiphilic Dipeptides

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• 作者：Aseem Mishra ; Jiban Jyoti Panda ; Atanu Basu ; Virander Singh Chauhan
• 刊名：Langmuir
• 出版年：2008
• 出版时间：May 6, 2008
• 年：2008
• 卷：24
• 期：9
• 页码：4571 - 4576
• 全文大小：402K
• 年卷期：v.24,no.9(May 6, 2008)
• ISSN：1520-5827

文摘

Peptide-based vesicular structures have been the focus of research in the past decade for their potential applicationas drug delivery agents. We here report the self-assembly of amphiphilic dipeptides containing conformation-constrainings/gifchars/alpha.gif" BORDER=0>,s/gifchars/beta2.gif" BORDER=0 ALIGN="middle">-dehydrophenylalanine into nanovesicles. The vesicles can encapsulate small drug molecules such as riboflavinand vitamin B₁₂, bioactive peptides, and small protein molecules. The nanovesicles are resistant to treatment of anonspecific protease, proteinase K, and are stable at low concentrations of monovalent and divalent cations. Thevesicles are effectively taken up by actively growing cells in culture and show no observable cytopathic effects. Thesepeptide-based nanostructures can be considered as models for further development as delivery agents for differentbiomolecules.