Resistance by Allostery: A Novel Perspective for Eg5-Targeted Drug Design

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• 作者：Ambily Nath Indu Viswanath ; Ae Nim Pae
• 刊名：Journal of Medicinal Chemistry
• 出版年：2013
• 出版时间：August 22, 2013
• 年：2013
• 卷：56
• 期：16
• 页码：6314-6316
• 全文大小：164K
• 年卷期：v.56,no.16(August 22, 2013)
• ISSN：1520-4804

文摘

Talapatra et al. elucidated the molecular basis of resistance by characterizing the binding interactions between Eg5 and the allosteric inhibitor SB743921. The investigation, employing biochemical, biophysical, and structural analyses, made path-breaking revelations in Eg5 studies and discussed a novel phenomenon 鈥渞esistance by allostery鈥? which could have far-reaching consequences from a rational drug design perspective.