Enzyme-Based Logic: OR Gate with Double-Sigmoid Filter Response

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• 作者：Oleksandr Zavalov ; Vera Bocharova ; Vladimir Privman ; Evgeny Katz
• 刊名：The Journal of Physical Chemistry B
• 出版年：2012
• 出版时间：August 16, 2012
• 年：2012
• 卷：116
• 期：32
• 页码：9683-9689
• 全文大小：371K
• 年卷期：v.116,no.32(August 16, 2012)
• ISSN：1520-5207

文摘

The first realization of a biomolecular OR gate function with double-sigmoid response (sigmoid in both inputs) is reported. Two chemical inputs activate the enzymatic gate processes, resulting in the output signal: chromogen oxidation, which occurs when either one of the inputs or both are present (corresponding to the OR binary function), and can be optically detected. High-quality gate functioning in handling of sources of noise is enabled by 鈥渇iltering鈥?involving pH control with an added buffer. The resulting gate response is sigmoid in both inputs when proper system parameters are chosen, and the gate properties are theoretically analyzed within a model devised to evaluate its noise-handling properties.