Mussel-Inspired Multidentate Block Copolymer to Stabilize Ultrasmall Superparamagnetic Fe3O4 for Magnetic Resonance Imaging Contrast Enhancement and Excellent Colloidal Stability

详细信息    查看全文

• 作者：Puzhen Li ; Pascale Chevallier ; Parsarm Ramrup ; Depannita Biswas ; Dajana Vuckovich ; Marc-Andr茅 Fortin ; Jung Kwon Oh
• 刊名：Chemistry of Materials
• 出版年：2015
• 出版时间：October 27, 2015
• 年：2015
• 卷：27
• 期：20
• 页码：7100-7109
• 全文大小：506K
• ISSN：1520-5002

文摘

Colloidal ultrasmall superparamagnetic iron oxide nanoparticles (USNPs) with better control of their surface chemistry have been considered as a biocompatible alternative to clinically used gadolinium-based contrast agents for in vivo bright magnetic resonance imaging (MRI). Herein, we report a versatile mussel-inspired multidentate block copolymer strategy that allows for the stabilization of USNPs as promising MRI contrast agents with excellent colloidal stability. A well-controlled multidentate block copolymer with pendant multiple catechol groups (Cat-MDBC) is synthesized by a combination of controlled radical polymerization and postmodification methods. The Cat-MDBC proves to be effective to strongly anchor to USNP surfaces as well as provide optimal hydrophilic surfaces, thus enabling the fabrication of aqueous Cat-MDBC/USNP colloids at single layers with a diameter of 鈮?0 nm through a biphasic ligand exchange process. They exhibit excellent colloidal stability in broad pH range and physiological conditions; no significant protein adsorption; and great magnetic properties including relaxivity and in vitro MRI. Further comparison of Cat-MDBC with its corresponding catechol-based multidentate random copolymer suggests the importance of the architecture of multidentate polymeric ligands for USNP-based MRI diagnosis.