Organocatalytic Enantioselective Friedel−Crafts Alkylation of 4,7-Dihydroindoles with α,β-Unsaturated Aldehydes: An Easy Access to 2-Substituted Indoles

详细信息    查看全文

• 作者：Liang Hong ; Chunxia Liu ; Wangsheng Sun ; Lei Wang ; Kwokyin Wong ; Rui Wang
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：May 21, 2009
• 年：2009
• 卷：11
• 期：10
• 页码：2177-2180
• 全文大小：121K
• 年卷期：v.11,no.10(May 21, 2009)
• ISSN：1523-7052

文摘

An enantioselective Friedel−Crafts alkylation of 4,7-dihydroindoles and α,β-unsaturated aldehydes has been developed. The process is promoted by diphenylprolinol ether to afford 2-substituted 4,7-dihydroindoles in high yields and enantioselectivities. After a subsequent oxidation of the products, the optically active 2-substituted indoles could be obtained smoothly in high yields without any loss of enantioselectivity.