Alkoxyamine-derived Formamidines: Configurational Control and Molecular Folding

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• 作者：Weiwen Zhao ; Ruiyao Wang ; Nicholas J. Mosey ; Anne Petitjean
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：October 7, 2011
• 年：2011
• 卷：13
• 期：19
• 页码：5160-5163
• 全文大小：790K
• 年卷期：v.13,no.19(October 7, 2011)
• ISSN：1523-7052

文摘

N,N鈥?Disubstituted formamidines, and amidines in general, have very rich configurational, conformational, and tautomeric diversities. As part of an effort to incorporate alkoxyamine-derived formamidine units into foldamers, the first evidence for the isolation of the up-to-now unknown E isomer, the conditions for its exclusive formation, its stability and self-assembly properties, and its configurational isomerization to its much more common Z counterpart are reported. Considering the distinctly different H-bonding patterns displayed by both E and Z isomers, such configurational control may find applications in self-assembly, molecular recognition, and biomimetic systems.