Lathyrane Diterpenoids from the Roots of Euphorbia micractina and Their Biological Activities

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• 作者：Ye Tian ; Wendong Xu ; Chenggen Zhu ; Sheng Lin ; Yanru Li ; Liang Xiong ; Sujuan Wang ; Ling Wang ; Yongchun Yang ; Ying Guo ; Hua Sun ; Xiaoliang Wang ; Jiangong Shi
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：May 27, 2011
• 年：2011
• 卷：74
• 期：5
• 页码：1221-1229
• 全文大小：858K
• 年卷期：v.74,no.5(May 27, 2011)
• ISSN：1520-6025

文摘

Seventeen new lathyrane diterpenoids (1鈥?b>17) and two known analogues have been isolated from an ethanolic extract of Euphorbia micractina roots. Their structures including absolute configurations were determined by spectroscopic data interpretation and single-crystal X-ray crystallography. Compound 10 showed activity against HIV-1 replication in vitro, with an IC₅₀ value of 8.2 渭M. Compounds 6, 7, 11, 14, 15, and 18, at 10^鈥? M, showed significant vascular-relaxing activities against phenylephrine-induced vasoconstriction with relaxation rates of 48%, 41%, 42%, 48%, 50%, and 53%, respectively.