Diterpenoids with Diverse Skeletons from the Roots of Euphorbia micractina

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• 作者：Ye Tian ; Wendong Xu ; Chenggen Zhu ; Sheng Lin ; Ying Guo ; Jiangong Shi
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：June 28, 2013
• 年：2013
• 卷：76
• 期：6
• 页码：1039-1046
• 全文大小：286K
• 年卷期：v.76,no.6(June 28, 2013)
• ISSN：1520-6025

文摘

Twelve new minor diterpenoids, possessing 5/6/8 (1 and 2), 5/6/7/3 (3鈥?b>9), and 5/6/6/4 (10鈥?b>12) fused-ring skeletons, as determined by spectroscopic analysis, were isolated from an ethanol extract of the roots of Euphorbia micractina, together with 25 known compounds. The structures of the diterpene skeletons are rare and have been found only in compounds isolated from Euphorbia micractina and Euphorbia villosa. On the basis of the octant rule for cyclohexanones, the absolute configurations of 1鈥?b>12, as well as of the known euphactins A鈥揇 and euphoractins A鈥揇 (13鈥?b>15), could be assigned by circular dichroism spectroscopy. In addition, the co-occurring jolkinol B (16) was chemically transformed to euphoractin E (17), supporting the absolute configuration assignment and the biogenetic relationship between the different types of diterpenes. Compound 9 showed activity against HIV-1 replication in vitro, with an IC₅₀ value of 8.8 卤 0.6 渭M.