Sorbicillamines A鈥揈, Nitrogen-Containing Sorbicillinoids from the Deep-Sea-Derived Fungus Penicillium sp. F23鈥?
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- 作者：Wenqiang Guo ; Jixing Peng ; Tianjiao Zhu ; Qianqun Gu ; Robert A. Keyzers ; Dehai Li
- 刊名：Journal of Natural Products
- 出版年：2013
- 出版时间：November 22, 2013
- 年：2013
- 卷：76
- 期：11
- 页码：2106-2112
- 全文大小：393K
- 年卷期：v.76,no.11(November 22, 2013)
- ISSN：1520-6025
文摘
Five new nitrogen-containing sorbicillinoids named sorbicillamines A鈥揈 (1鈥?b>5) were isolated from an agitated culture of the deep-sea-derived fungus Penicillium sp. F23鈥?, which has previously produced indole alkaloids and terpenoids when cultured under static conditions. The structures of 1 to 5, including absolute configurations, were determined based on MS, NMR, and circular dichroism (CD) data. The cytotoxicities of the five new sorbicillin alkaloids against the HeLa, BEL-7402, HEK-293, HCT-116, and P388 cell lines were evaluated.