Chiral Amide Directed Assembly of a Diastereo- and Enantiopure Supramolecular Host and its Application to Enantioselective Catalysis of Neutral Substrates

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• 作者：Chen Zhao ; Qing-Fu Sun ; William M. Hart-Cooper ; Antonio G. DiPasquale ; F. Dean Toste ; Robert G. Bergman ; Kenneth N. Raymond
• 刊名：Journal of the American Chemical Society
• 出版年：2013
• 出版时间：December 18, 2013
• 年：2013
• 卷：135
• 期：50
• 页码：18802-18805
• 全文大小：277K
• 年卷期：v.135,no.50(December 18, 2013)
• ISSN：1520-5126

文摘

The synthesis of a novel supramolecular tetrahedral assembly of K₁₂Ga₄L₆ stoichiometry is reported. The newly designed chiral ligand exhibits high diastereoselective control during cluster formation, leading exclusively to a single diastereomer of the desired host. This new assembly also exhibits high stability toward oxidation or a low pH environment and is a more robust and efficient catalyst for asymmetric organic transformations of neutral substrates.