Sensitive Biological Detection with a Soluble and Stable Polymeric Paramagnetic Nanocluster

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• 作者：Benjamin Kim ; Anne H. Schmieder ; Allen J. Stacy ; Todd A. Williams ; Dipanjan Pan
• 刊名：The Journal of the American Chemical Society
• 出版年：2012
• 出版时间：June 27, 2012
• 年：2012
• 卷：134
• 期：25
• 页码：10377-10380
• 全文大小：258K
• 年卷期：v.134,no.25(June 27, 2012)
• ISSN：1520-5126

文摘

We describe the design, synthesis, and biological characterization of manganese oxocluster-based 鈥渟ingle molecule magnets (SMMs)鈥? We demonstrate that polymeric micellar nanoparticles can serve as a carrier and help to stabilize delicate SMM molecules from breaking down easily and thus prevent their property loss. Concentrating thousands of Mn-clusters per micelle provided a high ionic and per-particle relaxivity allowing sensitive MR imaging in vivo. This reports one of the earliest examples of in vivo imaging of a rationally designed polymeric micelle that features SMM.