Flavanones and Chromones from Salicornia herbacea Mitigate Septic Lethality via Restoration of Vascular Barrier Integrity
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- 作者：Nguyen Quoc Tuan ; Wonhwa Lee ; Joonseok Oh ; Roshan Rajan Kulkarni ; Charlotte G茅ny ; Byeongjin Jung ; Hyejin Kang ; Jong-Sup Bae ; MinKyun Na
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2015
- 出版时间：November 25, 2015
- 年：2015
- 卷：63
- 期：46
- 页码：10121-10130
- 全文大小：512K
- ISSN：1520-5118
文摘
Salicornia herbacea is an annual halophytic glasswort that has been employed as a culinary vegetable, salad, and traditional medicinal resource. Chemical investigation of the aerial parts of S. herbacea led to the isolation of two new (1, 2) and known (3) flavanones as well as a new nature-derived (4) and two known chromone derivatives (5, 6). These purified compounds were evaluated for their suppressive potentials against the release of high-mobility group box 1 protein (HMGB1), which has captured attention as a viable target for alleviating serious septic manifestations or septicemia. The phenolic compounds improved the survival rates of cecal ligation and puncture operation (CLP) in murine models, simulating severe septic shock and its related complications, to 40鈥?0%. These results collectively validate that flavanone- and chromone-based secondary metabolites may serve as prospective prodrugs or food additives that may be commercialized for the control of septic complications and lethality.