Copper-Catalyzed Aerobic C(sp2)鈥揌 Functionalization for C鈥揘 Bond Formation: Synthesis of Pyrazoles and Indazoles
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- 作者：Xianwei Li ; Li He ; Huoji Chen ; Wanqing Wu ; Huanfeng Jiang
- 刊名：The Journal of Organic Chemistry
- 出版年：2013
- 出版时间：April 19, 2013
- 年：2013
- 卷：78
- 期：8
- 页码：3636-3646
- 全文大小：460K
- 年卷期：v.78,no.8(April 19, 2013)
- ISSN：1520-6904
文摘
A simple, practical, and highly efficient synthesis of pyrazoles and indazoles via copper-catalyzed direct aerobic oxidative C(sp2)鈥揌 amination has been reported herein. This process tolerated a variety of functional groups under mild conditions. Further diversification of pyrazoles was also investigated, which provided its potential for drug discovery.