Radical鈥揚olar Crossover Reactions: Oxidative Coupling of 1,3-Dioxolanes with Electron-Deficient Alkenes and Vinylarenes Based on a Radical Addition and Kornblum鈥揇eLaMare Rearrangement

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• 作者：Peng Du ; Huihuang Li ; Yaxiong Wang ; Jiang Cheng ; Xiaobing Wan
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：December 19, 2014
• 年：2014
• 卷：16
• 期：24
• 页码：6350-6353
• 全文大小：381K
• ISSN：1523-7052

文摘

A new radical-polar crossover reaction has been developed involving the combination of a tandem radical reaction and Kornblum鈥揇eLaMare rearrangement in a one-pot process. This simple methodology allows for the construction of polyfunctionalized carbonyl compounds via the oxidative coupling of 1,3-dioxolanes with electron-deficient alkenes and vinylarenes in the presence of Co(salen) and TBHP under mild conditions. This reaction also exhibited high functional group tolerance, wide substrate scope, and operational simplicity.