Au(I)-Catalyzed Efficient Synthesis of Functionalized Bicyclo[3.2.0]heptanes

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• 作者：Guotao Li ; Xiaogen Huang ; Liming Zhang
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：June 4, 2008
• 年：2008
• 卷：130
• 期：22
• 页码：6944 - 6945
• 全文大小：328K
• 年卷期：v.130,no.22(June 4, 2008)
• ISSN：1520-5126

文摘

An efficient Au(I)-catalyzed synthesis of highly strained and functionalized bicyclo[3.2.0]heptanes is developed. Subsequent couplings with various nucleophiles offer additional structural features/complexity. These one-pot, three-component reactions are proposed to proceed via a key 1,3-dipolar cycloaddition between a Au carbenoid-containing carbonyl ylide and ethyl vinyl ether.