A Facile One-Step in situ Functionalization of Quantum Dots with Preserved Photoluminescence for Bioconjugation
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- 作者：Qiangbin Wang ; Yang Xu ; Xiaohang Zhao ; Yung Chang ; Yan Liu ; Lijing Jiang ; Jaswinder Sharma ; Dong-Kyun Seo ; Hao Yan
- 刊名：Journal of the American Chemical Society
- 出版年：2007
- 出版时间：May 23, 2007
- 年：2007
- 卷：129
- 期：20
- 页码：6380 - 6381
- 全文大小：412K
- 年卷期：v.129,no.20(May 23, 2007)
- ISSN：1520-5126
文摘
Herein we report a new and simple method of in situ functionalization of CdSe QDs and surface passivation by a thin ZnS shell at the same time. This method avoids a second-step ligand exchange after the core-shell formation and preserved high quantum yield of the QDs. We demonstrated that such prepared QDs can serve as excellent nanomaterial for bioconjugation. Different antibodies were conjugated to the MPA-functionalized QDs and resulted in highly stable and highly photoluminescent nanoparticles for cell labeling purposes.