TiO2 Nanoparticles Functionalized Monolithic Capillary Microextraction Online Coupled with Inductively Coupled Plasma Mass Spectrometry for the Analysis of Gd Ion and Gd-Based Contrast Agen

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• 作者：Xiaolan Liu ; Beibei Chen ; Lin Zhang ; Shiyao Song ; Yabing Cai ; Man He ; Bin Hu
• 刊名：Analytical Chemistry
• 出版年：2015
• 出版时间：September 1, 2015
• 年：2015
• 卷：87
• 期：17
• 页码：8949-8956
• 全文大小：397K
• ISSN：1520-6882

文摘

In this work, a novel method of TiO₂ nanoparticles (NPs) functionalized monolithic capillary microextraction (CME) online coupling with inductively coupled plasma mass spectrometry (ICPMS) was developed for the sequential determination of Gd³⁺ and Gd-based contrast agents in human urine samples. The monolithic capillary was prepared by embedding anatase TiO₂ NP_S in the poly(methacrylic acid-ethylene glycol dimethacrylate) (MAA-EDMA) framework. The Gd³⁺ and Gd-based contrast agents (such as gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) and Gd-DTPA-bismethylamide (Gd-DTPA-BMA)) display different adsorption behaviors on the prepared monolithic capillary which possesses the adsorption properties of both anatase TiO₂ NP_S and poly(MAA-EDMA) monolith. Under the optimized conditions, the limits of detection (LODs) were found to be 3.6, 3.2, and 4.5 ng L^鈥? for Gd³⁺, Gd-DTPA, and Gd-DTPA-BMA, respectively, which are the lowest up to date. The enrichment factor was 25-fold with the sample throughput of 5 h^鈥?. The proposed method was validated by the analysis of Gd³⁺ and Gd-DTPA in the healthy human urine samples as well as Gd³⁺ and Gd-DTPA-BMA in patient urine samples. It was found that only a small amount of the free Gd³⁺ was released from Gd-DTPA-BMA, and accurate results could be obtained since no oxidation/reduction or subtraction is involved in this method. This method is simple, sensitive, and rapid and provides a very attractive nonchromatography strategy for the speciation of Gd³⁺ and Gd-based contrast agents in urine samples.