Chelator-Free 64Cu-Integrated Gold Nanomaterials for Positron Emission Tomography Imaging Guided Photothermal Cancer Therapy

详细信息    查看全文

• 作者：Xiaolian Sun ; Xinglu Huang ; Xuefeng Yan ; Yu Wang ; Jinxia Guo ; Orit Jacobson ; Dingbin Liu ; Lawrence P. Szajek ; Wenlei Zhu ; Gang Niu ; Dale O. Kiesewetter ; Shouheng Sun ; Xiaoyuan Chen
• 刊名：ACS Nano
• 出版年：2014
• 出版时间：August 26, 2014
• 年：2014
• 卷：8
• 期：8
• 页码：8438-8446
• 全文大小：569K
• ISSN：1936-086X

文摘

Using positron emission tomography (PET) imaging to monitor and quantitatively analyze the delivery and localization of Au nanomaterials (NMs), a widely used photothermal agent, is essential to optimize therapeutic protocols to achieve individualized medicine and avoid side effects. Coupling radiometals to Au NMs via a chelator faces the challenges of possible detachment of the radiometals as well as surface property changes of the NMs. In this study, we reported a simple and general chelator-free ⁶⁴Cu radiolabeling method by chemically reducing ⁶⁴Cu on the surface of polyethylene glycol (PEG)-stabilized Au NMs regardless of their shape and size. Our ⁶⁴Cu-integrated NMs are proved to be radiochemically stable and can provide an accurate and sensitive localization of NMs through noninvasive PET imaging. We further integrated ⁶⁴Cu onto arginine-glycine-aspartic acid (RGD) peptide modified Au nanorods (NRs) for tumor theranostic application. These NRs showed high tumor targeting ability in a U87MG glioblastoma xenograft model and were successfully used for PET image-guided photothermal therapy.

Keywords:

⁶⁴Cu labeling; chelator free; PET; image-guided photothermal therapy