Copper-Catalyzed Aza-Diels–Alder Reaction and Halogenation: An Approach To Synthesize 7-Halogenated Chromenoquinolines

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• 作者：Xiaoqiang Yu ; Jiao Wang ; Zhanwei Xu ; Yoshinori Yamamoto ; Ming Bao
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：May 20, 2016
• 年：2016
• 卷：18
• 期：10
• 页码：2491-2494
• 全文大小：362K
• 年卷期：0
• ISSN：1523-7052

文摘

A new halogenation method to construct halogen-substituted quinoline moieties is described. The Cu-catalyzed intramolecular aza-Diels–Alder reaction and halogenation reaction proceeded smoothly under mild conditions to produce the corresponding 7-chloro-6H-chromeno[4,3-b]quinolines and 7-chloro-6H-thiochromeno[4,3-b]quinolines in satisfactory yields.