Highly Enantioselective Cascade Reaction Catalyzed by Squaramides: the Synthesis of CF3-Containing Chromanes

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• 作者：Yuanyuan Zhu ; Xiaoyuan Li ; Qiao Chen ; Jinhuan Su ; Fengjing Jia ; Shuai Qiu ; Mingxia Ma ; Quantao Sun ; Wenjin Yan ; Kairong Wang ; Rui Wang
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：August 7, 2015
• 年：2015
• 卷：17
• 期：15
• 页码：3826-3829
• 全文大小：434K
• ISSN：1523-7052

文摘

A catalytic asymmetric method for the synthesis of 2-CF₃ chromanes has been described. Generally, the squaramide-catalyzed cascade reaction of 2-hydroxychalcones with 尾-CF₃-nitroalkenes gave the CF₃-containing heterocyclic compounds bearing three contiguous stereogenic centers in excellent yields, diastereoselectivities, and enantioselectivities.