Asymmetric Total Synthesis and Revision of the Absolute Configuration of 4-Keto-Clonostachydiol

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• 作者：Junjie Han ; Yingpeng Su ; Tuo Jiang ; Yanfen Xu ; Xing Huo ; Xuegong She ; Xinfu Pan
• 刊名：Journal of Organic Chemistry
• 出版年：2009
• 出版时间：May 15, 2009
• 年：2009
• 卷：74
• 期：10
• 页码：3930-3932
• 全文大小：165K
• 年卷期：v.74,no.10(May 15, 2009)
• ISSN：1520-6904

文摘

The first total synthesis of the 14-membered natural macrocyclic bislactone 4-keto-clonostachydiol, along with its enantiomer, has been accomplished in 13 steps with overall yields of 8.4% and 8.0%, respectively. The absolute configuration of 4-keto-clonostachydiol 1 has been revised as (5S,10S,13S).