Sequential Intermolecular Aminopalladation/ortho-Arene C-H Activation Reactions of N-Phenylpropiolamides with Phthalimide

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• 作者：Shi Tang ; Peng Peng ; Shao-Feng Pi ; Yun Liang ; Nai-Xing Wang ; Jin-Heng Li
• 刊名：Organic Letters
• 出版年：2008
• 出版时间：March 20, 2008
• 年：2008
• 卷：10
• 期：6
• 页码：1179 - 1182
• 全文大小：91K
• 年卷期：v.10,no.6(March 20, 2008)
• ISSN：1523-7052

文摘

<TABLE>A novel palladium-catalyzed intermolecular aminopalladation/C-H activation method for selectively synthesizing (E)-(2-oxindolin-3-ylidene)phthalimides has been developed. In the presence of Pd(OAc)₂ and PhI(OAc)₂, alkynes were difunctionalized with a phthalimide and an arenesp² C-H bond to selectively synthesize (E)-(2-oxoindolin-3-ylidene)phthalimides, which products are of great potential pharmaceutical valueproducts in many major therapeutic areas, such as oncology, inflammation, neurology, immunology, and endocrinology. To the best of ourknowledge, the reaction serves as the first example of intermolecular aminopalladation/C-H activation reactions of alkynes.