Polydopamine-Coated Magnetic Composite Particles with an Enhanced Photothermal Effect

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• 作者：Rui Zheng ; Sheng Wang ; Ye Tian ; Xinguo Jiang ; Deliang Fu ; Shun Shen ; Wuli Yang
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2015
• 出版时间：July 29, 2015
• 年：2015
• 卷：7
• 期：29
• 页码：15876-15884
• 全文大小：551K
• ISSN：1944-8252

文摘

Recently, photothermal therapy (PTT) that utilizes photothermal conversion (PTC) agents to ablate cancer under near-infrared (NIR) irradiation has attracted a growing amount of attention because of its excellent therapeutic efficacy and improved target selectivity. Therefore, exploring novel PTC agents with an outstanding photothermal effect is a current research focus. Herein, we reported a polydopamine-coated magnetic composite particle with an enhanced PTC effect, which was synthesized simply through coating polydopamine (PDA) on the surface of magnetic Fe₃O₄ particles. Compared with magnetic Fe₃O₄ particles and PDA nanospheres, the core鈥搒hell nanomaterials exhibited an increased NIR absorption, and thus, an enhanced photothermal effect was obtained. We demonstrated the in vitro and in vivo effects of the photothermal therapy using our composite particles and their ability as a contrast agent in the T₂-weighted magnetic resonance imaging. These results indicated that the multifunctional composite particles with enhanced photothermal effect are superior to magnetic Fe₃O₄ particles and PDA nanospheres alone.