Decaspirones F-I, Bioactive Secondary Metabolites from the Saprophytic Fungus Helicoma viridis
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- 作者：Hejiao Hu ; Huijuan Guo ; Erwei Li ; Xingzhong Liu ; Yuguang Zhou ; Yongsheng Che
- 刊名：Journal of Natural Products
- 出版年：2006
- 出版时间：December 2006
- 年：2006
- 卷：69
- 期：12
- 页码：1672 - 1675
- 全文大小：88K
- 年卷期：v.69,no.12(December 2006)
- ISSN：1520-6025
文摘
Decaspirones F-H (1-3), three new spirobisnaphthalene derivatives, and one new non-spirobisnaphthalene, decaspironeI (4), have been isolated from cultures of an isolate of the saprophytic fungus Helicoma viridis. The structures of thesecompounds were determined mainly by analysis of their NMR spectroscopic data. The absolute configuration ofdecaspirone F (1) was established by X-ray crystallographic analysis of its mono-bromobenzoate derivative. In standarddisk assays, compounds 1-4 showed modest activity against Pseudomonas aeruginosa (multiple antibiotic-resistantstrain, ATCC 27853), and decaspirone G (2) also displayed activity against Lactococcus lacti (PCM 2379).