Tandem Reactions Leading to Bicyclic Pyrimidine Nucleosides and Benzopyran-4-ones

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• 作者：Xuesen Fan ; Yangyang Wang ; Yingying Qu ; Haiyun Xu ; Yan He ; Xinying Zhang ; Jianji Wang
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：February 4, 2011
• 年：2011
• 卷：76
• 期：3
• 页码：982-985
• 全文大小：840K
• 年卷期：v.76,no.3(February 4, 2011)
• ISSN：1520-6904

文摘

A novel, rapid, and efficient synthesis of bicyclic pyrimidine nucleosides and benzopyran-4-ones through oxidation of homopropargyl alcohols and subsequent isomerization, intramolecular addition of enol to allenic ketone has been developed. This methodology provides an efficient and promising approach to the structurally and pharmaceutically interesting pyrano[2,3-d]pyrimidine-2,5-dione nucleoside and benzopyran-4-one derivatives.