Development of Triphenylamine Functional Dye for Selective Photoelectrochemical Sensing of Cysteine

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• 作者：Shuo Wu ; Honglei Song ; Jie Song ; Cheng He ; Jun Ni ; Yanqiu Zhao ; Xiuyun Wang
• 刊名：Analytical Chemistry
• 出版年：2014
• 出版时间：June 17, 2014
• 年：2014
• 卷：86
• 期：12
• 页码：5922-5928
• 全文大小：360K
• 年卷期：v.86,no.12(June 17, 2014)
• ISSN：1520-6882

文摘

A novel triphenylamine-based organic dye, TTA, with an acrylic group is designed to graft TiO₂ nanoparticles for sensitive and selective photoelectrochemical sensing. The synthesized TTA possesses a high molar absorption coefficient, leading to an enhanced photoelectron emission ability of the electron donor. The carboxyl group of TTA acts as not only an electron acceptor but also a linker to connect TTA to TiO₂ nanoparticles. Under irradiation, TTA shows fast intramolecular charge transfer from triphenylamine to carboxyl group via the 蟺-bridge of thiophene moiety, thus producing a sensitive photocurrent response. Meanwhile, the acrylic moiety provides an active site for the Michael addition reaction, which would destroy the 蟺-bridge and decrease the photocurrent response. Thus, a selective photoelectrochemical sensing strategy is proposed for detection of small biomolecules. Using cysteine as a model analyte, this sensing strategy shows a detectable range from 1 to 200 渭M, without the interference from natural amino acids and various biological reducing reagents. This work offers a new photoelectrochemical route to highly selective and sensitive detection of biologically important small molecules.