Syntheses of d-Glucose Derivatives Emitting Blue Fluorescence through Pd-Catalyzed C–N Coupling

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• 作者：Yuji Otsuka ; Ayako Sasaki ; Tadashi Teshima ; Katsuya Yamada ; Toshihiro Yamamoto
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：March 18, 2016
• 年：2016
• 卷：18
• 期：6
• 页码：1338-1341
• 全文大小：404K
• ISSN：1523-7052

文摘

Green fluorescence-emitting d-glucose derivatives such as 2-NBDG have been effectively used to monitor d-glucose uptake through glucose transporters GLUTs at the single cell level. By contrast, GLUT-permeable d-glucose derivatives emitting blue fluorescence have been long awaited. A glucose tracer, 2-deoxy-2-(2-oxo-2H-chromen-7-yl)amino-d-glucose (CDG) (1), together with related compounds have been synthesized by Pd-catalyzed C–N coupling. Of these, CDG (1) is a promising blue fluorescence-emitting candidate molecule that may enter into mammalian cells through GLUTs.