Enantiopure 1,2-Bis(tert-butylmethylphosphino)benzene as a Highly Efficient Ligand in Rhodium-Catalyzed Asymmetric Hydrogenation
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- 作者：Ken Tamura ; Masashi Sugiya ; Kazuhiro Yoshida ; Akira Yanagisawa ; Tsuneo Imamoto
- 刊名：Organic Letters
- 出版年：2010
- 出版时间：October 1, 2010
- 年：2010
- 卷：12
- 期：19
- 页码：4400-4403
- 全文大小：182K
- 年卷期：v.12,no.19(October 1, 2010)
- ISSN：1523-7052
文摘
An electron-rich P-stereogenic bisphosphine ligand named “BenzP*” was conveniently prepared from o-dibromobenzene and enantiopure tert-butylmethylphosphine-borane. Its rhodium complex exhibited excellent enantioselectivities of up to 99.9% and high catalytic activity of up to 10000 h−1 TOF in asymmetric hydrogenations of various functionalized alkenes.