Robust Polydiacetylene-Based Colorimetric Sensing Material Developed with Amyloid Fibrils of 伪-Synuclein

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• 作者：Jee Eun Yang ; Jae Sung Park ; Eunae Cho ; Seunho Jung ; Seung R. Paik
• 刊名：Langmuir
• 出版年：2015
• 出版时间：February 10, 2015
• 年：2015
• 卷：31
• 期：5
• 页码：1802-1810
• 全文大小：624K
• ISSN：1520-5827

文摘

Robust polydiacetylene-based colorimetric sensing material has been developed with amyloid fibrils of 伪-synuclein in the presence of 10,12-pentacosadiynoic acid (PCDA) by taking advantage of the specific fatty acid interaction of 伪-synuclein and structural regularity of the self-assembled product of amyloid fibrils. PCDA facilitated not only self-oligomerization of 伪-synuclein but also its fibrillation into the fibrils with increased thickness. Upon UV irradiation, the PCDA-containing amyloid fibrils (AF-PCDAs) turned blue, which then became red following heat treatment. The blue-to-red color transition was also observed with other stimuli of pH and ethanol. AF-PCDAs were demonstrated to be mechanically stable since not only the individual colors of blue and red but also their colorimetric transition were not affected by a number of sonications which readily disrupted the polydiaceylene (PDA) vesicles with the instant loss of color. Therefore, AF-PCDA can be considered to be a novel PDA-based colorimetric sensing material with high mechanical strength, which has the potential to be employed in various areas involving advanced sensing technologies.