Synthesis of Polycarbonyl Pyrroles via K2S2O8-Mediated Oxidative Cyclization of Enamines

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• 作者：Peng Gao ; Juan Wang ; Zi-Jing Bai ; Li Shen ; Yun-Yun Yan ; De-Suo Yang ; Ming-Jin Fan ; Zheng-Hui Guan
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：December 2, 2016
• 年：2016
• 卷：18
• 期：23
• 页码：6074-6077
• 全文大小：442K
• ISSN：1523-7052

文摘

A novel K₂S₂O₈-promoted oxidative cyclization of enamines is described. A variety of enamines having diverse functional groups and substitution patterns react well using K₂S₂O₈ as the oxidant in the absence of catalyst. This protocol provides a very simple route for the synthesis of polycarbonyl pyrroles and has the advantages of readily available starting materials, mild reaction conditions, and a wide scope of substrates.