Erythronolides H and I, New Erythromycin Congeners from a New Halophilic Actinomycete Actinopolyspora sp. YIM90600

详细信息    查看全文

• 作者：Sheng-Xiong Huang^† ; ^‡ ; ; Li-Xing Zhao^† ; ^§ ; ; Shu-Kun Tang^§ ; ; Cheng-Lin Jiang^§ ; ; Yanwen Duan^‡ ; ; B
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：March 19, 2009
• 年：2009
• 卷：11
• 期：6
• 页码：1353-1356
• 全文大小：129K
• 年卷期：v.11,no.6(March 19, 2009)
• ISSN：1523-7052

文摘

Erythronolides H and I, novel congeners of the clinically important antibacterial drug erythromycin A, have been isolated from the new halophilic actinomycete Actinopolyspora sp. YIM90600. In addition to producing the new erythromycin congeners, A. sp. YIM90600 produces erythromycin C in a high titer. The presence of the C-14 hydroxyl moiety and the C-6/C-18-epoxide in erythronolide H and the spiroketal moiety of erythronolide I sheds new insights into structural diversity of erythromycin analog libraries potentially accessible by combinatorial biosynthesis.