Bioactive Clerodane Diterpenoids from the Twigs of Casearia balansae

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• 作者：Jing Xu ; Qiang Zhang ; Meicheng Wang ; Quanhui Ren ; Yihang Sun ; Da-Qing Jin ; Chunfeng Xie ; Hongqiang Chen ; Yasushi Ohizumi ; Yuanqiang Guo
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：October 24, 2014
• 年：2014
• 卷：77
• 期：10
• 页码：2182-2189
• 全文大小：328K
• ISSN：1520-6025

文摘

Eight new clerodane diterpenes, balanspenes A鈥揌 (1鈥?b>8), along with two known analogues (9 and 10), were isolated from the twigs of Casearia balansae. The structures of 1鈥?b>8 were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analysis, and the absolute configurations of compounds 1, 4, and 7 were confirmed by comparing their experimental CD spectra with those calculated by the time-dependent density functional theory method. Compounds 4鈥?b>7, 9, and 10 were found to possess the property of being able to stimulate NGF-mediated neurite outgrowth from PC12 cells.