Asymmetric Intermolecular Pauson−Khand Reaction of Symmetrically Substituted Alkynes

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• 作者：Yining Ji ; Antoni Riera ; Xavier Verdaguer
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：October 1, 2009
• 年：2009
• 卷：11
• 期：19
• 页码：4346-4349
• 全文大小：199K
• 年卷期：v.11,no.19(October 1, 2009)
• ISSN：1523-7052

文摘

The asymmetric intermolecular Pauson−Khand reaction of symmetric alkynes has been accomplished for the first time. N-Phosphino-p-tolylsulfinamide (PNSO) ligands have been indentified as efficient ligands in this process. The chirality of the cobalt S-bonded sulfinyl moiety was found to direct olefin insertion into one of the two possible cobalt−carbon bonds in the alkyne complex. Reaction of symmetric alkynes allows for a simplified experimental protocol since there is no need for separation of diastereomeric complexes.