Multiplexing Natural Orientation: Oppositely Directed Self-Assembling Peptides

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• 作者：Woo-jin Jeong ; Sanghun Han ; Hyeseo Park ; Kyeong Sik Jin ; Yong-beom Lim
• 刊名：Biomacromolecules
• 出版年：2014
• 出版时间：June 9, 2014
• 年：2014
• 卷：15
• 期：6
• 页码：2138-2145
• 全文大小：548K
• 年卷期：v.15,no.6(June 9, 2014)
• ISSN：1526-4602

文摘

We explore here the possibility that polypeptide chains with directional multiplicity might provide for the control of peptide self-assembly processes. We tested this new possibility using an oppositely directed peptide (ODP) supramolecular system. The ODP could make it possible to form a 尾伪尾 motif with antiparallel 尾-sheets, which does not exist in nature. Furthermore, the designed ODPs were able to self-assemble into discrete, homogeneous, and structured protein-like controlled nano-objects. ODPs represent a simple but powerful unnatural self-assembling peptide system that can become a basic scaffold for fabricating more complex and elaborate artificial nanostructures.