LC-MS-Guided Isolation of Penicilfuranone A: A New Antifibrotic Furancarboxylic Acid from the Plant Endophytic Fungus Penicillium sp. sh18

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• 作者：Wei-Guang Wang ; Ao Li ; Bing-Chao Yan ; Shu-Bin Niu ; Jian-Wei Tang ; Xiao-Nian Li ; Xue Du ; Gregory L. Challis ; Yongsheng Che ; Han-Dong Sun ; Jian-Xin Pu
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：January 22, 2016
• 年：2016
• 卷：79
• 期：1
• 页码：149-155
• 全文大小：505K
• ISSN：1520-6025

文摘

Penicilfuranone A (1), a novel furancarboxylic acid, and its proposed biosynthetic precursor, gregatin A (2), were isolated from the cultures of the fungus Penicillium sp. sh18 endophytic to the stems of Isodon eriocalyx var. laxiflora guided by HPLC-MS. X-ray crystallography was applied to the structure determination of furancarboxylic acid for the first time, allowing unambiguous assignment of 1. Penicilfuranone A displays a significant antifibrotic effect in activated hepatic stellate cells via negative regulation of transforming growth factor-β (TGF-β)/Smad signaling.