Copper-Catalyzed Arylation of o-Bromoanilides: Highly Flexible Synthesis of Hexahydropyrroloindole Alkaloids

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• 作者：Yongyun Zhou ; Yongkai Xi ; Jingfeng Zhao ; Xianfu Sheng ; Shuqin Zhang ; Hongbin Zhang
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：June 15, 2012
• 年：2012
• 卷：14
• 期：12
• 页码：3116-3119
• 全文大小：307K
• 年卷期：v.14,no.12(June 15, 2012)
• ISSN：1523-7052

文摘

In the presence of catalytic amount of copper iodide, a remote amide-assisted intramolecular arylation followed by alkylation leads to a general and flexible synthetic method toward the synthesis of medicinally interesting hexahydropyrroloindole alkaloids.