General Synthesis of Sugar-Derived Azepane Nitrones: Precursors of Azepane Iminosugars
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- 作者：Wen-Bo Zhao ; Shinpei Nakagawa ; Atsushi Kato ; Isao Adachi ; Yue-Mei Jia ; Xiang-Guo Hu ; George W. J. Fleet ; Francis X. Wilson ; Graeme Horne ; Akihide Yoshihara ; Ken Izumori ; Chu-Yi Yu
- 刊名：The Journal of Organic Chemistry
- 出版年：2013
- 出版时间：April 5, 2013
- 年：2013
- 卷：78
- 期：7
- 页码：3208-3221
- 全文大小：598K
- 年卷期：v.78,no.7(April 5, 2013)
- ISSN：1520-6904
文摘
A general and efficient method has been developed for the synthesis of sugar-derived azepane nitrones starting from aldohexoses, with an intramolecular condensation of aldehyde and hydroxylamine as the key step. Through this strategy, each aldohexose produced a pair of azepane nitrones, which are precursors of various azepane iminosugars.