Picrajavanicins A–G, Quassinoids from Picrasma javanica Collected in Myanmar

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• 作者：Nwet Nwet Win ; Takuya Ito ; Ismail ; Takeshi Kodama ; Yi Yi Win ; Masami Tanaka ; Hla Ngwe ; Yoshinori Asakawa ; Ikuro Abe ; Hiroyuki Morita
• 刊名：Journal of Natural Products
• 出版年：2015
• 出版时间：December 24, 2015
• 年：2015
• 卷：78
• 期：12
• 页码：3024-3030
• 全文大小：342K
• ISSN：1520-6025

文摘

Seven new tetracyclic quassinoids, picrajavanicins A–G (1–7), along with three known analogues, were isolated from a CHCl₃-soluble extract of the bark of Picrasma javanica collected in Myanmar. The structures of these compounds were elucidated using spectroscopic techniques, including 1D and 2D NMR. The absolute configuration at C-2 of 2 was determined to be S by the modified Mosher method. All the isolates were tested for their antiproliferative activities against a small panel of five human cancer cell lines. However, none of the isolated compounds exhibited inhibitory activity against any of the cancer cells used (IC₅₀ values >10 μM).