Jellyfish-Shaped Amphiphilic Dendrimers: Synthesis and Formation of Extremely Uniform Aggregates

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• 作者：Shiqun Shao ; Jingxing Si ; Jianbin Tang ; Meihua Sui ; Youqing Shen
• 刊名：Macromolecules
• 出版年：2014
• 出版时间：February 11, 2014
• 年：2014
• 卷：47
• 期：3
• 页码：916-921
• 全文大小：443K
• ISSN：1520-5835

文摘

Novel classes of jellyfish-shaped amphiphilic dendrimers composed of 7 hydrophilic poly(ethylene glycol) (PEG) arms and 14 hydrophobic polyester dendrons with 尾-cyclodextrin (尾CD) as the core molecule were synthesized by a facile method. Seven PEG chains were first conjugated to the C-6 positions of native 尾CD. Subsequently, dendritic polyester architectures were constructed from the remaining 14 secondary hydroxyl groups at C-2 and C-3 positions of the 尾CD moiety, resulting in jellyfish-shaped amphiphilic dendrimers of different generations (7PEG-尾CD-Gx) with well-defined molecular structures. The amphiphilic dendrimers self-assembled into different morphologies dependent upon the hydrophilic fraction of the dendrimers, and very surprisingly, the fourth-generation dendrimers consisting of only several percent of PEG could form aggregates with extremely narrow size distributions.