Isolation, Characterization, and Antiproliferative Activities of Eudesmanolide Derivatives from the Flowers of Inula japonica

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• 作者：Chunfeng Xie ; Hao Wang ; Xiaocong Sun ; Linghao Meng ; Meicheng Wang ; Mark Bartlam ; Yuanqiang Guo
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2015
• 出版时间：October 21, 2015
• 年：2015
• 卷：63
• 期：41
• 页码：9006-9011
• 全文大小：298K
• ISSN：1520-5118

文摘

Inula japonica belongs to the family Asteraceae, and its flowers have been used as dietary supplements and health tea in China. The study aimed to identify the bioactive components with the antiproliferative property. Ten 1,10-seco-eudesmanolide derivatives, including four new compounds (1鈥?b>4), were isolated from the flowers of I. japonica. Their structures were established on the basis of the interpretation of spectroscopic data and electronic circular dichroism (ECD) calculations. All of these isolates were evaluated for their antiproliferative activities against MCF-7 and MDA-MB-231 human breast cancer cells. Compound 4 possessed the most potent effects, with the IC₅₀ values of 0.20 卤 0.04 and 6.22 卤 1.30 渭M against MCF-7 and MDA-MB-231 cells, respectively. The present investigation indicated that eudesmanolide derivatives from the flowers of I. japonica, especially compound 4, might be used as potential antitumor chemotherapy agent candidates.