A New Metabolite with a Unique 4-Pyranone鈭捨?Lactam鈥?,4-Thiazine Moiety from a Hawaiian-Plant Associated Fungus
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- 作者：Chun-Shun Li ; Yuanqing Ding ; Bao-Jun Yang ; Gabriella Miklossy ; Hong-Quan Yin ; Larry A. Walker ; James Turkson ; Shugeng Cao
- 刊名：Organic Letters
- 出版年：2015
- 出版时间：July 17, 2015
- 年：2015
- 卷：17
- 期：14
- 页码：3556-3559
- 全文大小：271K
- ISSN：1523-7052
文摘
An endophytic fungus Paraphaeosphaeria neglecta FT462 isolated from the Hawaiian-plant Lycopodiella cernua (L.) Pic. Serm produced one unusual compound (1, paraphaeosphaeride A) with the 4-pyranone鈭捨?lactam鈥?,4-thiazine moiety, along with two new compounds (2 and 3, paraphaeosphaerides B and C, respectively) and the known compound (4). Compounds 1鈥?b>3 were characterized by NMR and MS spectroscopic analysis. The absolute configuration of the 3-position of compound 1 was determined as S by electronic circular dichroism (ECD) calculations. Compound 3 also showed STAT3 inhibition at 10 渭M.