Antidiabetic Ellagitannins from Pomegranate Flowers: Inhibition of 伪-Glucosidase and Lipogenic Gene Expression
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- 作者：Tao Yuan ; Yuanqing Ding ; Chunpeng Wan ; Liya Li ; Jialin Xu ; Ke Liu ; Angela Slitt ; Daneel Ferreira ; Ikhlas A. Khan ; Navindra P. Seeram
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：October 19, 2012
- 年：2012
- 卷：14
- 期：20
- 页码：5358-5361
- 全文大小：245K
- 年卷期：v.14,no.20(October 19, 2012)
- ISSN：1523-7052
文摘
Two new ellagitannins containing a rare 3-oxo-1,3,3a,8b-tetrahydrofuro[3,4-b]benzofuran moiety, namely punicatannins A (1) and B (2), were isolated from pomegranate (Punica granatum) flowers. Their structures with absolute configuration were determined by detailed analysis of spectroscopic data, electronic circular dichroism (ECD) calculation, and chemical hydrolysis. A plausible biogenetic route involving a key enzymatic 1,4-Michael addition is proposed. Punicatannin A showed potent inhibition of 伪-glucosidase and lipogenic gene expression.