Decarboxylative Halogenation and Cyanation of Electron-Deficient Aryl Carboxylic Acids via Cu Mediator as Well as Electron-Rich Ones through Pd Catalyst under Aerobic Conditions
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- 作者：Zhengjiang Fu ; Zhaojie Li ; Yuanyuan Song ; Ruchun Yang ; Yanzhu Liu ; Hu Cai
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：April 1, 2016
- 年：2016
- 卷：81
- 期：7
- 页码：2794-2803
- 全文大小：491K
- ISSN：1520-6904
文摘
Simple strategies for decarboxylative functionalizations of electron-deficient benzoic acids via using Cu(I) as promoter and electron-rich ones by employing Pd(II) as catalyst under aerobic conditions have been established, which lead to smooth synthesis of aryl halides (−I, Br, and Cl) through the decarboxylative functionalization of benzoic acids with readily available halogen sources CuX (X = I, Br, Cl), and easy preparation of benzonitriles from decarboxylative cyanation of aryl carboxylic acids with nontoxic and low-cost K4Fe(CN)6 under an oxygen atmosphere for the first time.