Acid鈥揃ase Jointly Promoted Copper(I)-Catalyzed Azide鈥揂lkyne Cycloaddition

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• 作者：Changwei Shao ; Xinyan Wang ; Qun Zhang ; Sheng Luo ; Jichen Zhao ; Yuefei Hu
• 刊名：Journal of Organic Chemistry
• 出版年：2011
• 出版时间：August 19, 2011
• 年：2011
• 卷：76
• 期：16
• 页码：6832-6836
• 全文大小：847K
• 年卷期：v.76,no.16(August 19, 2011)
• ISSN：1520-6904

文摘

In this novel acid鈥揵ase jointly promoted CuAAC, the combination of CuI/DIPEA/HOAc was developed as a highly efficient catalytic system. The functions of DIPEA and HOAc have been assigned, and HOAc was recognized to accelerate the conversions of the C鈥揅u bond-containing intermediates and buffer the basicity of DIPEA. As a result, all drawbacks occurring in the popular catalytic system CuI/NR₃ were overcome easily.