Carbene-Catalyzed Dynamic Kinetic Resolution of Carboxylic Esters

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• 作者：Xingkuan Chen ; Jacqueline Zi Mei Fong ; Jianfeng Xu ; Chengli Mou ; Yunpeng Lu ; Song Yang ; Bao-An Song ; Yonggui Robin Chi
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：June 15, 2016
• 年：2016
• 卷：138
• 期：23
• 页码：7212-7215
• 全文大小：505K
• 年卷期：0
• ISSN：1520-5126

文摘

Carbene-catalyzed reaction of carboxylic esters has the potential to offer effective synthetic solutions that cannot be readily achieved by using the more conventional aldehyde-type substrates. Here we report the first carbene-catalyzed dynamic kinetic resolution of α,α-disubstituted carboxylic esters with up to 99:1 er and 99% yield. The present study clearly illustrates the unique power of carbene-catalyzed reactions of readily available and easy to handle carboxylic esters.