Intramolecular Functionalization of Benzylic Methylene Adjacent to the Ring Nitrogen Atom in N-Aryltetrahydroisoquinoline Derivatives

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• 作者：Liu Yang ; Daisy Zhang-Negrerie ; Kang Zhao ; Yunfei Du
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：April 15, 2016
• 年：2016
• 卷：81
• 期：8
• 页码：3372-3379
• 全文大小：462K
• 年卷期：0
• ISSN：1520-6904

文摘

Functionalization at the benzylic methylene group that is adjacent to the ring nitrogen atom in a series of N-aryltetrahydroisoquinoline compounds has been realized through intramolecular cross-dehydrogenative coupling reactions. The presented transformation provided straightforward access to the formation of C(sp³)–Y (Y = C, N or O) bond via I(III) reagent.