Melamine-Induced Urolithiasis in a Drosophila Model

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• 作者：Wen-Chi Chen ; Wei-Yong Lin ; Huey-Yi Chen ; Chiao-Hui Chang ; Fuu-Jen Tsai ; Kee-Ming Man ; Jui-Lung Shen ; Yung-Hsiang Chen
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2012
• 出版时间：March 14, 2012
• 年：2012
• 卷：60
• 期：10
• 页码：2753-2757
• 全文大小：252K
• 年卷期：v.60,no.10(March 14, 2012)
• ISSN：1520-5118

文摘

Melamine-tainted food can induce renal stones in both humans and animals. We have previously reported a novel Drosophila model for the study of renal stone disease. In addition to hyperoxaluria-causing agents, we also tested herein the effect of melamine on crystal formation in Drosophila. The results indicate that administration of melamine alone caused crystal formation in a dose-dependent manner. The crystals also appeared after ingestion of melamine for 3 weeks in the Malpighian tubules of Drosophila when viewed with polarized light. Administration of potassium citrate (K citrate) was found to significantly ameliorate the melamine-induced reduction of lifespan. However, administration of K citrate failed to reduce the quantity of crystals. Because calcium oxalate is not the major crystal induced by melamine, the predominant components of melamine-induced crystals and the potential crystal inhibitors warrant further investigation.

Keywords:

Drosophila melanogaster; melamine; urolithiasis; potassium citrate