Silver-Catalyzed, Aldehyde-Induced α-C–H Functionalization of Tetrahydroisoquinolines with Concurrent C–P Bond Formation/N-Alkylation
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- 作者：Gaobo Hu ; Weizhu Chen ; Dumei Ma ; Yun Zhang ; Pengxiang Xu ; Yuxing Gao ; Yufen Zhao
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：February 19, 2016
- 年：2016
- 卷：81
- 期：4
- 页码：1704-1711
- 全文大小：426K
- ISSN：1520-6904
文摘
The first facile and efficient silver-catalyzed, aldehyde-induced three-component reaction of N-unprotected tetrahydroisoquinolines, aldehydes, and dialkyl phosphonates has been developed, providing a general one-step approach to structurally diverse C1-phosphonylated THIQs accompanied by concurrent C–P bond formation/N-alkylation with remarkable functional group tolerance and excellent regioselectivity for endo products.